Dr. David Jürgens
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David Jürgens, né Keul (PhD Student)
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Since Oct 2024, Postdoc, LMU Munich |
| Publications: |
Hagedorn L, Jürgens DC, Merkel, O.M, Winkeljann B*: Endosomal escape mechanisms of extracellular vesicle-based drug carriers: lessons for lipid nanoparticle design. Extracellular Vesicles and Circulating Nucleic Acids 5 (3), 344-357 David C. Jürgens, Joschka T. Müller, Anny Nguyen, Olivia M Merkel*: Tailoring lipid nanoparticles for T-cell targeting in allergic asthma: Insights into efficacy and specificity. Friederike Adams, Christoph M Zimmermann, Domizia Baldassi, Thomas M Pehl, Philipp Weingarten, Iris Kachel, Moritz Kränzlein, David C Jürgens, Peter Braubach, Ioannis Alexopoulos, Malgorzata Wygrecka, Olivia M Merkel*: Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis. David C Jürgens, Benjamin Winkeljann, Miriam Kolog Gulko, Yoa Jin, Judith Möller, Joshua Winkeljann, Sahana Sheshachala, Alina Anger, Andreas Hörner, Nathan B P Adams, Nora Urbanetz, Olivia M Merkel*: Efficient and Targeted siRNA Delivery to M2 Macrophages by Smart Polymer Blends for M1 Macrophage Repolarization as a Promising Strategy for Future Cancer Treatment. Christoph M. Zimmermann, Leonie Deßloch, David C Jürgens, Paola Luciani, Olivia M. Merkel: Evaluation of the effects of storage conditions on spray-dried siRNA-LNPs before and after subsequent drying. Natascha Hartl, David C Jürgens, Simone Carneiro, Ann-Christine König, Ximian Xiao, Runhui Liu, Stefanie M Hauck, Olivia M Merkel*: Protein corona investigations of polyplexes with varying hydrophobicity - From method development to in vitro studies. David C Jürgens, Leonie Deßloch, Diana Porras-Gonzalez, Joshua Winkeljann, Sebastian Zielinski, Matthias Munschauer, Andreas L. Hörner, Gerald Burgstaller, Benjamin Winkeljann, Olivia M Merkel*: Lab-scale siRNA and mRNA LNP manufacturing by various microfluidic mixing techniques – an evaluation of particle properties and efficiency. Rima Kandil, Domizia Baldassi, Sebastian Böhlen, Joschka T Müller, David C Jürgens, Tonia Bargmann, Susann Dehmel, Yuran Xie, Aditi Mehra, Olivia M Merkel*: GATA3 knockdown in activated T cells via pulmonary siRNA delivery as novel therapy for allergic asthma. Yao Jin, Friederike Adams, Judith Möller, Lorenz Isert, Christoph Zimmermann, David Keul, Olivia M Merkel*: Synthesis and Application of Low Molecular Weight PEI-Based Copolymers for siRNA Delivery with Smart Polymer Blends. Engineering poly-and micelleplexes for nucleic acid delivery–A reflection on their endosomal escape |
