Publications
Original Peer Reviewed ResearchBarlang LA, Deimel I, Mohl BP, Blaurock C, Balkema-Buschmann A, Weinbender K, Hess B, Obernolte H, Merkel OM, Popp A: Distribution and suitability of pulmonary surfactants as a vehicle for topically applied antibodies in healthy and SARS-CoV-2 infected rodent lungs. Frey N*, Ouologuem L*, Blenninger J, Siow WX, Thorn-Seshold J, Stöckl J, Abrahamian C, Fröhlich T, Vollmar AM, Grimm C, Bartel K: Endolysosomal TRPML1 channel regulates cancer cell migration by altering intracellular trafficking of E-cadherin and β1-integrin. David C. Jürgens, Joschka T. Müller, Anny Nguyen, Olivia M Merkel*: Tailoring lipid nanoparticles for T-cell targeting in allergic asthma: Insights into efficacy and specificity. Jonas Binder, Joshua Winkeljann, Katharina Steinegger, Lara Trnovec, Daria Orekhova, Jonas Zähringer, Andreas Hörner, Valentin Fell, Philip Tinnefeld, Benjamin Winkeljann, Wolfgang Frieß, Olivia M Merkel*: Closing the Gap between Experiment and Simulation─ A Holistic Study on the Complexation of Small Interfering RNAs with Polyethylenimine. Friederike Adams, Christoph M Zimmermann, Domizia Baldassi, Thomas M Pehl, Philipp Weingarten, Iris Kachel, Moritz Kränzlein, David C Jürgens, Peter Braubach, Ioannis Alexopoulos, Malgorzata Wygrecka, Olivia M Merkel*: Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis. Natascha Hartl, Bettina Gabold, Philipp Uhl, Adrian Kromer, Ximian Xiao, Walter Mier, Gert Fricker, Runhui Liu, Olivia M Merkel*:ApoE-functionalization of nanoparticles for targeted brain delivery-a feasible method for polyplexes? David C Jürgens, Benjamin Winkeljann, Miriam Kolog Gulko, Yoa Jin, Judith Möller, Joshua Winkeljann, Sahana Sheshachala, Alina Anger, Andreas Hörner, Nathan B P Adams, Nora Urbanetz, Olivia M Merkel*: Efficient and Targeted siRNA Delivery to M2 Macrophages by Smart Polymer Blends for M1 Macrophage Repolarization as a Promising Strategy for Future Cancer Treatment. Lea-Adriana Barlang, Kristina Weinbender, Olivia M Merkel, Andreas Popp: SARS-CoV-2 induced changes in the glycosylation pattern in the respiratory tract of Golden Syrian hamsters. Christoph M. Zimmermann, Leonie Deßloch, David C Jürgens, Paola Luciani, Olivia M. Merkel: Evaluation of the effects of storage conditions on spray-dried siRNA-LNPs before and after subsequent drying. Karla Rubio, Jason M Müller, Aditi Mehta, Iris Watermann, Till Olchers, Ina Koch, Sabine Wessels, Marc A Schneider, Tania Araujo-Ramos, Indrabahadur Singh, Christian Kugler, Mircea Gabriel Stoleriu, Mark Kriegsmann, Martin Eichhorn, Thomas Muley, Olivia M Merkel, Thomas Braun, Ole Ammerpohl, Martin Reck, Achim Tresch, Guillermo Barreto: Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score. Yao Jin, Friederike Adams, Anny Nguyen, Sebastian Sturm, Simone Carneiro, Olivia M Merkel*: Synthesis and application of spermine-based amphiphilic poly(β-amino ester)s for siRNA delivery. Yao Jin, Friederike Adams, Lorenz Isert, Domizia Baldassi, Olivia M Merkel*: Spermine-Based Poly(β-amino ester)s for siRNA Delivery against Mutated KRAS in Lung Cancer. Lea-Adriana Barlang, Björn-Patrick Mohl, Claudia Blaurock, Sophia Harder, Angele Breithaupt, Olivia M Merkel, Anne Balkema-Buschmann, Andreas Popp: SARS-CoV-2 induced changes in the glycosylation pattern in the respiratory tract of Golden Syrian hamsters. Natascha Hartl, David C Jürgens, Simone Carneiro, Ann-Christine König, Ximian Xiao, Runhui Liu, Stefanie M Hauck, Olivia M Merkel*: Protein corona investigations of polyplexes with varying hydrophobicity - From method development to in vitro studies. Natascha Hartl, Bettina Gabold, Friederike Adams, Philipp Uhl, Sabrina Oerter, Sabine Gätzner, Marco Metzger, Ann-Christine König, Stefanie M Hauck, Antje Appelt-Menzel, Walter Mier, Gert Fricker, Olivia M Merkel*: Overcoming the blood-brain barrier? - prediction of blood-brain permeability of hydrophobically modified polyethylenimine polyplexes for siRNA delivery into the brain with in vitro and in vivo models. David C Jürgens, Leonie Deßloch, Diana Porras-Gonzalez, Joshua Winkeljann, Sebastian Zielinski, Matthias Munschauer, Andreas L. Hörner, Gerald Burgstaller, Benjamin Winkeljann, Olivia M Merkel*: Lab-scale siRNA and mRNA LNP manufacturing by various microfluidic mixing techniques – an evaluation of particle properties and efficiency. Antonietta Greco, Bettina Gabold, Siyu Chen, Xioaxuan Wang, Zehua Xu, Achim Hartschuh, Enrica Chiesa, Ida Genta, Christian L Ried, Thomas Merdan, Olivia M Merkel*: Microfluidic mixing as platform technology for production of chitosan nanoparticles loaded with different macromolecules. Lorenz Isert, Aditi Mehta, Gabriele Loiudice, Altea Oliva, Andreas Roidl, Olivia M Merkel*: An In-Vitro Approach to Model EMT in Breast Cancer. Rima Kandil, Domizia Baldassi, Sebastian Böhlen, Joschka T Müller, David C Jürgens, Tonia Bargmann, Susann Dehmel, Yuran Xie, Aditi Mehra, Olivia M Merkel*: GATA3 knockdown in activated T cells via pulmonary siRNA delivery as novel therapy for allergic asthma. Yao Jin, Friederike Adams, Judith Möller, Lorenz Isert, Christoph Zimmermann, David Keul, Olivia M Merkel*: Synthesis and Application of Low Molecular Weight PEI-Based Copolymers for siRNA Delivery with Smart Polymer Blends. Domizia Baldassi, Thi May Hanh Ngo, Olivia M Merkel*: Optimization of lung surfactant coating of siRNA polyplexes for pulmonary delivery. Bettina Gabold, Friederike Adams, Sophie Brameyer, Kirsten Jung, Christian L. Ried, Thomas Merdan, Olivia M Merkel*:Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins. Christoph M. Zimmermann, Domizia Baldassi, Karen Chan, Nathan B.P. Adams, Alina Neumann, Diana Porras-Gonzalez, Xin Wei, Nikolaus Kneidinger, Mircea Gabriel Stoleriu, Andreas Popp, Gerald Burgstaller, Dominik Witzigmann, Paola Luciani, Olivia M. Merkel*: Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery Tobias W.M. Keil, Natalie Deiringer, Wolfgang Friess, Olivia M. Merkel*: Evaluation of adsorption of DNA/PEI polyplexes to tubing materials Edmar R Oliveira-Filho, Matheus A de Macedo, Aline CC Lemos, Friederike Adams, Olivia M. Merkel, Marilda K Taciro, José Gregório C Gomzez, Luiziana F Silva: Engineering Burkholderia sacchari to enhance poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(3HB-co-3HHx)] production from xylose and hexanoate Domizia Baldassi, Shubhankar Ambike, Martin Feuerherd, Cho-Chin Cheng, David J Peeler, Daniel P Feldmann, Diana Porras-Gonzalez, Xin Wei, Lea Adriana Keller, Nikolaus Kneidinger, Mircea Gabriel Stoleriu, Andreas Popp, Gerald Burgstaller, Suzie H Pun, Thomas Michler, Olivia M. Merkel*: Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes Gemma Conte, Gabriella Costabile, Domizia Baldassi, Valeria Rondelli, Rosaria Bassi, Diego Colombo, Giulia Linardos, Ersilia V. Fiscarelli, Raffaella Sorrentino, Agnese Miro, Fabiana Quaglia, Paola Brocca, Ivana d’Angelo, Olivia M. Merkel, Francesca Ungaro: Hybrid lipid/polymer nanoparticles to tackle the cystic fibrosis mucus barrier in siRNA delivery to the lungs: does PEGylation make the difference? Shubhankar Ambike, Cho-Chin Cheng, Stoyan Velkov, Martin Feuerherd, Domizia Baldassi, Suliman Afridi, Diana Porras-Gonzalez, Xin Wei, Philipp Hagen, Nikolaus Kneidinger, Mircea Gabriel Stoleriu, Vincent Grass, Gerald Burgstaller, Andreas Pichlmair, Olivia Merkel, Chunkyu Ko, Thomas Michler: Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread.- Tobias W.M. Keil, Christoph Zimmermann, Domizia Baldassi, Friederike Adams, Wolfgang Friess, Aditi Mehta, Olivia M Merkel*: Impact of Crystalline and Amorphous Matrices on Successful Spray Drying of siRNA Polyplexes for Inhalation of Nano‐in‐Microparticles. Shubhankar Ambike, Cho-Chin Cheng, Suliman Afridi, Martin Feuerherd, Philipp Hagen, Vincent Grass, Olivia Merkel, Andreas Pichlmair, Chunkyu Ko, Thomas Michler: Systematic analysis of RNAi-accessible SARS-CoV-2 replication steps identifies ORF1 as promising target. Tobias W.M. Keil, Olivia M Merkel*: Characterization of positively charged polyplexes by tunable resistive pulse sensing. Daniel P Feldmann, Joshua Heyza, Christoph M. Zimmermann, Steve M. Patrick, Olivia M Merkel*: Nanoparticle-Mediated Gene Silencing for Sensitization of Lung Cancer to Cisplatin Therapy. Patrick Strack Raimund Külzer, Florian Sommer, Tom Bretschneider, Olivia M Merkel, Achim Grube*: A Smart Approach to Enable Preclinical Studies in Pharmaceutical Industry: PLGA-based Extended Release Formulation Platform for Subcutaneous Applications Tobias W.M. Keil, Daniel P. Feldmann, Gabriella Costabilea, Qian Zhong, Sandro da Rocha, Olivia M Merkel*: Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles Aditi Mehta, Elena Dalle Vedove, Lorenz Isert, Olivia M Merkel*: Targeting KRAS mutant lung cancer cells with siRNA-loaded Bovine Serum Albumin nanoparticles Natascha Hartl, Friederike Adams, Gabriella Costabile, Lorenz Isert, Markus Döblinger, Ximian Xiano, Runhui Liu, Olivia M Merkel*: The Impact of Nylon-3 Copolymer Composition on the Efficiency of siRNA Delivery to Glioblastoma Cells. Rima Kandil, Yuran Xie, Ralf Heermann, Lorenz Isert, Kirsten Jung, Aditi Mehta, Olivia M Merkel*: Coming in and Finding Out: Blending Receptor‐Targeted Delivery and Efficient Endosomal Escape in a Novel Bio‐Responsive siRNA Delivery System for Gene Knockdown in Pulmonary T Cells. Moses Andima, Gabriella Costabile, Lorenz Isert, Albert J Ndakala, Solomon Derese, Olivia M Merkel*: Evaluation of β-Sitosterol Loaded PLGA and PEG-PLA Nanoparticles for Effective Treatment of Breast Cancer: Preparation, Physicochemical Characterization, and Antitumor Activity. Gabriella Costabile, Kathrin I Gasteyer, Venkatareddy Nadithe, Katherine Van Denburgh, Qian Lin, Shiv Sharma, Joshia J Reineke, Steven M Firestine, Olivia M Merkel*: Physicochemical and In Vitro Evaluation of Drug Delivery of an Antibacterial Synthetic Benzophenone in Biodegradable PLGA Nanoparticles. Steven K Jones, Kirk Douglas, Anthony F Shields, Olivia M Merkel*: Correlating quantitative tumor accumulation and gene knockdown using SPECT/CT and bioluminescence imaging within an orthotopic ovarian cancer model. Elena Dalle Vedove, Gabriella Costabile, Olivia M Merkel*: Mannose and Mannose-6-Phosphate Receptor-Targeted Drug Delivery Systems and Their Application in Cancer Therapy. Daniel P Feldmann, Yilong Cheng, Rima Kandil, Yuran Xie, Mariam Mohammadi, Hartmann Harz, Akhil Sharma, David J. Peeler, Anna Moszczynska, Heinrich Leonhardt, Suzie H. Pun, Olivia M Merkel*: In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells. Jickssa M. Gemechu, Akhil Sharma, Dongyue Yu, Yuran Xie, Olivia M Merkel, Anna Moszczynska: Characterization of Dopaminergic System in the Striatum of Young Adult Park2−/−Knockout Rats. Steven K Jones, Anwesha Sarkar, Daniel P Feldmann, Peter Hoffmann, Olivia M Merkel*: Revisiting the value of competition assays in folate receptor-mediated drug delivery. Mariam Mohammadi, Ying Li, Daniel G Abebe, Yuran Xie, Rima Kandil, Teresa Kraus, Nardhy Gomez-Lopez, Tomoko Fujiwara, Olivia M Merkel*: Folate receptor targeted three-layered micelles and hydrogels for gene delivery to activated macrophages Biomacromolecules, 2016, 17 (1), 76-87 Li Liu, Mengyao Zheng, Damiano Librizzi, Thomas Renette, Olivia M Merkel*, Thomas Kissel: Efficient and Tumor Targeted siRNA Delivery by Polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol)-folate (PEI-PCL-PEG-Fol). Molecular Pharmaceutics, 2016, 13 (1), 134-43 Daniel Ghirmay Abebe, Rima Kandil, Teresa Kraus, Maha Elsayed, Olivia M Merkel*, Tomoko Fujiwara*: Three-Layered Biodegradable Micelles Prepared by Two-Step Self-Assembly of PLA-PEI-PLA and PLA-PEG-PLA Triblock Copolymers as Efficient Gene Delivery System Macromolecular Bioscience, 2015, 15 (5), 698-717 Venkatareddy Nadithe, Runhui Liu, Na Hyung Kim, Bryan Killinger, Anna Moszczynska, Kristyn S Masters, Samuel H Gellman, Olivia M Merkel*: Screening of Nylon-3 Polymers, a New Class of Cationic Amphiphiles for siRNA Delivery R. Michael Dutescu, Claudia Panfil, Olivia M Merkel, Norbert Schrage: Semifluorinated alkanes as liquid drug carrier systemfor topical ocular drug delivery Maha Elsayed, Vincent Corrand, Vidula Kolhatkar, Yuran Xie, Na Hyung Kim, Rohit Kolhatkar, Olivia M Merkel: The influence of oligospermine architecture on their suitability for siRNA delivery Thomas Endres, Mengyao Zheng, Ayşe Kılıç, Agnieszka Turowska, Moritz Beck-Broichsitter, Harald Renz, Olivia M. Merkel*, Thomas Kissel: Amphiphilic Biodegradable PEG-PCL-PEI Triblock Copolymers for FRET-Capable in Vitro and in Vivo Delivery of siRNA and Quantum Dots Agnieszka Turowska, Damiano Librizzi, Nadja Baumgartl, Jens Kuhlmann, Tanja Dicke, Olivia Merkel, Ursula Homburg, Helmut Höffken, Harald Renz, Holger Garn: Biodistribution of the GATA-3-specific DNAzyme hgd40 after inhalative exposure in mice, rats and dogs Mengyao Zheng, Giovanni M. Pavan, Manuel Neeb, Andreas Schaper, Andrea Danani, Gerhard Klebe, Olivia M. Merkel*, Thomas Kissel: Targeting the blind spot of polycationic nanocarrier-based siRNA delivery Mengyao Zheng, Damiano Librizzi, Ayşe Kılıç, Yu Liu, Harald Renz, Olivia M. Merkel*, Thomas Kissel: Enhancing in vivo circulation and siRNA delivery with biodegradable polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol) copolymers Thomas Renette, Damiano Librizzi, Thomas Endres, Moritz Beck-Broichsitter, Nadja Bege, Olivia M. Merkel, Holger Petersen, Catherine Curdy, Thomas Kissel:Poly(ethylene carbonate) nanoparticles as carrier system for chemotherapy showing prolonged in vivo circulation and anti-tumor efficacy Macromolecular Bioscience 2012, 12(7), 970-8 Olivia M. Merkel and Thomas Kissel: Pulmonary siRNA Delivery Nick D. Weber*, Olivia M. Merkel*, Thomas Kissel, María Angeles Muñoz-Fernández: PEGylated poly(ethylene imine) copolymer-delivered siRNA inhibits HIV replication in vitro Mengyao Zheng, Yu Liu, Olga Samsonova, Olivia Merkel, Thomas Kissel: Amphiphilic and biodegradable hy-PEI-g-PCL-b-PEG copolymers efficiently mediate transgene expression depending on their graft density Yu Liu, Olga Samsonova, Brian Sproat, Olivia Merkel, Thomas Kissel: Biophysical characterization of hyper-branched polyethylenimine-graft- polycaprolactone-block-mono-methoxyl-poly(ethylene glycol) copolymers (hy- PEI-PCL-mPEG) for siRNA and DNA delivery Olga Samsonova, Christian Pfeiffer, Markus Hellmund, Olivia Merkel*, Thomas Kissel: Low molecular weight pDMAEMA-b-pHEMA block-copolymers synthesized via RAFTPolymerization: potential non-viral gene delivery agents? Olivia M. Merkel, Rudolf Urbanics, Peter Bedocs, Zoltán Rozsnyay, László Rosivall, Miklós Toth, Thomas Kissel, Janos Szebeni: In vitro and in vivo Complement Activation and Related Anaphylactic Effects Associated with Polyethylenimine and Polyethylenimine-graft-poly(ethylene glycol) Block Copolymers Nadja Bege*, Thomas Renette*, Mirko Jansch, Regina Reul, Olivia Merkel, Holger Petersen, Catherine Curdy, Rainer H. Müller, Thomas Kissel: Poly(ethylene carbonate) nanoparticles: A novel biodegradable carrier system with “stealth” potential Olivia M. Merkel*, Mengyao Zheng, Meredith A Mintzer, Giovanni M Pavan, Damiano Librizzi, Marek Maley, Helmut Höffken, Andrea Danani, Eric E Simanek, Thomas Kissel: Molecular modeling and in vivo imaging can identify Andrea Beyerle, Andrea Braun, Olivia Merkel, Felix Koch, Thomas Kissel, Tobias Stoeger: Comparative in vivo study of poly(ethylene imine)/sirna complexes for pulmonary delivery in mice Olivia M. Merkel, Andrea Beyerle, Benedikt Beckmann, Mengyao Zheng, Roland Hartmann, Tobias Stoeger, Thomas Kissel: Polymer-related off-target effects in non-viral siRNA delivery Olivia M. Merkel, Meredith A. Mintzer, Damiano Librizzi, Olga Samsonova, Tanja Dicke, Brian Sproat, Holger Garn, Peter J. Barth, Eric E.Simanek, Thomas Kissel:Triazine dendrimers as non-viral vectors for in vitro and in vivo RNAi: The effects of peripheral groups and core structure on biological activity Giovanni M. Pavan, Meredith Mintzer, Eric Simanek, Olivia M. Merkel, Thomas Kissel, Andrea Danani: Computational Insights into the Interactions between DNA and siRNA with “Rigid” and “Flexible” Triazine Dendrimers Andrea Beyerle, Olivia M. Merkel, Tobias Stöger and Thomas Kissel: PEGylation affects cytotoxicity and cell-compatibility of poly(ethylene imine) for lung application: Structure–function relationships Olivia M. Merkel*, Meredith A. Mintzer*, Johannes Sitterberg, Udo Bakowsky, Eric E. Simanek and Thomas Kissel: Triazine dendrimers as nonviral gene delivery systems: effects of molecular structure on biological activity. Olivia M. Merkel, Andrea Beyerle, Damiano Librizzi, Andreas Pfestroff, Thomas M. Behr, Brian Sproat, Peter J. Barth, Thomas Kissel: Nonviral siRNA Delivery to the Lung: Investigation of PEG-PEI Polyplexes and Their In Vivo Performance Yu Liu, Juliane Nguyen, Terry Steele, Olivia Merkel, Thomas Kissel: A new synthesis method and degradation of hyper-branched polyethylenimine grafted polycaprolactone block mono-methoxyl poly (ethylene glycol) copolymers (hy-PEI-g-PCL-b-mPEG) as potential DNA delivery vectors Meredith A. Mintzer*, Olivia M. Merkel*, Thomas Kissel, Eric Simanek: Polycationic triazine-based dendrimers: Effect of peripheral groups on transfection efficiency Olivia M. Merkel, Oliver Germershaus, Carol K. Wada, Peter J. Tarcha, Thomas Merdan and Thomas Kissel: Integrin alpha-v-beta-3 targeted gene delivery using RGD peptidomimetic conjugates with copolymers of PEGylated poly(ethylene imine) Olivia M. Merkel, Damiano Librizzi, Andreas Pfestroff, Tino Schurrat, Kevin Buyens, Niek N. Sanders, Stefaan DeSmedt, Martin Béhé and Thomas Kissel: Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging Anastasia Malek, Olivia Merkel, Ludger Fink, Frank Czubayko, Thomas Kissel and Achim Aigner: In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes. Olivia M. Merkel, Damiano Librizzi, Andreas Pfestroff, Tino Schurrat, Martin Béhé and Thomas Kissel: In vivo SPECT and real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery after novel radio labeling and purification Juliane Nguyen*, Terry W.J. Steele*, Olivia Merkel, Regina Reul and Thomas Kissel: Fast degrading polyesters as siRNA nano-carriers for pulmonary gene therapy Shirui Mao, Michael Neu, Oliver Germershaus, Olivia Merkel, Johannes Sitterberg, Udo Bakowsky, Thomas Kissel: Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly (ethylene imine)-graft-poly (ethylene glycol) block copolymer/ siRNA polyplexes |
Peer Reviewed ReviewsOlivia M. Merkel*: Can pulmonary RNA delivery improve our pandemic preparedness? Hagar Labouta, Robert Langer, Pieter R Cullis, Olivia M Merkel, Mark R Prausnitz, Yasmine Gomaa, Dara S Nogueira, Tushar Kumeria: Role of drug delivery technologies in the success of COVID-19 vaccines: a perspective. Domizia Baldassi, Bettina Gabold, Olivia M. Merkel*: Air−Liquid Interface Cultures of the Healthy and Diseased Human Respiratory Tract: Promises, Challenges, and Future Directions. Aditi Mehta, Thomas Michler, Olivia M. Merkel*: siRNA Therapeutics against Respiratory Viral Infections-What Have We Learned for Potential COVID-19 Therapies? Lea-Adriana Keller, Olivia Merkel*, Andreas Popp: Intranasal drug delivery: opportunities and toxicologic challenges during drug development Natascha Hartl, Friederike Adams, Olivia M. Merkel*: From Adsorption to Covalent Bonding: Apolipoprotein E Functionalization of Polymeric Nanoparticles for Drug Delivery Across the Blood–Brain Barrier Tobias W. M. Keil, Domizia Baldassi, Olivia M. Merkel*: T‐cell targeted pulmonary siRNA delivery for the treatment of asthma, Aditi Mehta, Olivia M. Merkel*: Immunogenicity of Cas9 Protein. Rima Kandil, Olivia M. Merkel*: Recent Progress of Polymeric Nanogels for Gene Delivery. Haris Babačić, Aditi Mehta, Olivia M. Merkel, Benedikt Schoser: CRISPR-cas gene-editing as plausible treatment of neuromuscular and nucleotide-repeat-expansion diseases: A systematic review, Juergen Siepmann, Amina Faham, Sophie-Dorothée Clas, Ben J. Boyd, Vincent Jannin, Andreas Bernkop-Schnürch, Hang Zhao, Sébastien Lecommandoux, James C. Evans, Christine Allen, Olivia M. Merkel, Gabriella Costabile, Morgan R. Alexander, Ricky D. Wildman, Clive J. Robert, Jean-Christophe Leroux: Lipids and polymers in pharmaceutical technology: Lifelong companions, Steven Jones, Olivia M. Merkel*: Tackling Breast Cancer Chemoresistance with Nano-Formulated siRNA, Rima Kandil, Olivia M. Merkel*: Therapeutic Delivery of siRNA: Diseases affecting the respiratory system, Archiv der Pharmazie 2015, 348 (10), 681-688. Sara Movassaghian, Olivia M. Merkel, Vladimir Torchilin*: Applications of Polymer Micelles for Imaging and Drug Delivery, WIREs Nanomedicine and Nanobiotechnology 2014, 7 (5), 691-707. Olivia M. Merkel*, Thomas Kissel: Quo vadis polyplex?, Journal of Controlled Release 2014, 190, 415-23 Olivia M. Merkel*, Israel Rubinstein, Thomas Kissel: siRNA Delivery to the lung: What's new?, Advanced Drug Delivery Reviews 2014, 75:112-28 Maha Elsayed, Olivia M. Merkel*: Nanoimprinting of topographical and 3D cell culture scaffolds, Nanomedicine (London) 2014, 9 (2), 349-366 Na Hyung Kim, Venkatareddy Nadithe, Maha Elsayed, Olivia M. Merkel*: Tracking and treating activated T cells, Journal of Drug Delivery Science and Technology 2013, 23 (1), 17-21 Moritz Beck-Broichsitter, Olivia M. Merkel, Thomas Kissel: Controlled pulmonary drug and gene delivery using polymeric nano-carriers, Journal of Controlled Release 2012, 161(2), 214-24 Olivia M. Merkel, Mengyao Zheng, Heiko Debus, Thomas Kissel: Pulmonary Gene Delivery Using Polymeric Nonviral Vectors, Bioconjugate Chemistry 2012, 23(1), 3-20 |
Book Chapters and OthersAditi Mehta*, Olivia Merkel: Characterization Techniques for Studying the Properties of Nanocarriers for Systemic Delivery. Rima Kandil, Yuran Xie, Aditi Mehta, Olivia Merkel*: A Method for Targeted Nonviral siRNA Delivery in Cancer and Inflammatory Diseases. Daniel P Feldmann, Steven K Jones, Anthony F Shields, Olivia M Merkel*: Microfluidic Assembly of siRNA-Loaded Micelleplexes for Tumor Targeting in an Orthotopic Model of Ovarian Cancer. Gabriella Costabile, Olivia M. Merkel, Emerging Pulmonary Delivery Strategies in Gene Therapy: State of the Art and Future Considerations, Pharmaceutical Inhalation Aerosol Technology 2019, Chapter 15, CRC Press, pp.365-387. *Corresponding Author Tobias WM Keil, Olivia M. Merkel, Dry powder inhalation of siRNA, Therapeutic Delivery 2019, 10 (5), 265-267. Bettina Schwarz, Olivia M. Merkel, Nose-to-brain delivery of biologics, Therapeutic Delivery 2019, 10 (4), 207-210. Rima Kandil, Olivia M. Merkel, Pulmonary delivery of siRNA as a novel treatment for lung diseases, Therapeutic Delivery 2019, 10 (4), 203-206. Olivia M. Merkel*, Leigh Marsh, Holger Garn, Thomas Kissel: Flow cytometry-based cell type-specific assessment of target regulation by pulmonary siRNA delivery, Rima Kandil, Daniel Feldmann, Yuran Xie, Olivia M. Merkel*: Evaluating the Regulation of Cytokine Levels After siRNA Treatment in Antigen-Specific Target Cell Populations via Intracellular Staining, Bettina Schwarz, Olivia M. Merkel, Functionalized PEI and Its Role in Gene Therapy Rima Kandil, Jon Felt, Prashant Mahajan, Olivia M. Merkel: The Biology and Clinical Treatment of Asthma, Yuran Xie, Rima Kandil, Olivia M. Merkel: Bridging the Gap between the Bench and the Clinic: Asthma, Daniel G. Abebe, Rima Kandil, Teresa Kraus, Maha Elsayed, Tomoko Fujiwara, Olivia M. Merkel*: Biodegradable Three-Layered Micelles and Injectable Hydrogels, Methods in Molecular Biology 2016, 1445, 175-185. *Corresponding Author Steven Jones, Olivia M. Merkel*: Indium-Labeling of siRNA for small animal SPECT Imaging , Methods in Molecular Biology 2016, 1372, 79-88.*Corresponding Author Maha Elsayed, Olivia M. Merkel*: Inhaled Delivery of siRNA, "Advances and Challenges in the Delivery of Nucleic Acid Therapeutics", Vol 2, Future Science Press 2015. *Corresponding Author Daniel P. Feldmann, Olivia M. Merkel*: The advantages of pulmonary delivery of therapeutic siRNA, Therapeutic Delivery 2015, 6 (4), 407-9, Invited Editorial *Corresponding Author Mengyao Zheng, Thomas Kissel, Olivia M. Merkel*: Self-assembly of siRNA containing nanoparticles, Book Chapter in “RNA Nanotechnology and Therapeutics" , *Corresponding Author Olivia M. Merkel*, Leigh Marsh, Holger Garn, Thomas Kissel: Flow cytometry-based cell type-specific assessment of target regulation by pulmonary siRNA delivery, Meredith A. Mintzer, Olivia M. Merkel, Thomas Kissel, Eric E. Simanek: Triazine dendrimers for DNA and siRNA delivery: Progress, challenges, and opportunities Olivia M. Merkel*, Meredith A. Mintzer, Eric E. Simanek, Thomas Kissel: Perfectly shaped siRNA delivery Olivia M. Merkel*, Meredith A. Mintzer, Eric Simanek, Thomas Kissel: Systematically modifying triazine dendrimers for efficient RNAi Olivia M. Merkel*, Thomas Kissel: [Pulmonary application of siRNA] |