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Publications

Original Peer Reviewed Research

Jin Y, Wang X, Kromer APE, Müller J, Zimmermann C, Xu Z, Hartschuh A, Adams F, Merkel OM: Role of Hydrophobic Modification in Spermine-Based Poly(β-amino ester)s for siRNA Delivery and Their Spray-Dried Powders for Inhalation and Improved Storage
Biomacromolecules 2024, ahead of print, doi: 10.1021/acs.biomac.4c00283

Fischer P, Merkel OM, Siedler M, Huelsmeyer M: Development of a high throughput oxidation profiling strategy for monoclonal antibody products
Eur J Pharm Biopharm. 2024 199:114301. doi: 10.1016/j.ejpb.2024.114301.

Barlang LA, Deimel I, Mohl BP, Blaurock C, Balkema-Buschmann A, Weinbender K, Hess B, Obernolte H, Merkel OM, Popp A: Distribution and suitability of pulmonary surfactants as a vehicle for topically applied antibodies in healthy and SARS-CoV-2 infected rodent lungs.
Eur J Pharm Sci. 2024 Mar 11;196:106744. doi: 10.1016/j.ejps.2024.106744.

Frey N*, Ouologuem L*, Blenninger J, Siow WX, Thorn-Seshold J, Stöckl J, Abrahamian C, Fröhlich T, Vollmar AM, Grimm C, Bartel K: Endolysosomal TRPML1 channel regulates cancer cell migration by altering intracellular trafficking of E-cadherin and β1-integrin.
J Biol Chem. 2024 Jan;300(1):105581. doi: 10.1016/j.jbc.2023.105581.

David C. Jürgens, Joschka T. Müller, Anny Nguyen, Olivia M Merkel*: Tailoring lipid nanoparticles for T-cell targeting in allergic asthma: Insights into efficacy and specificity.
European Journal of Pharmaceutics and Biopharmaceutics 2024, doi:10.1016/j.ejpb.2024.114242

Jonas Binder, Joshua Winkeljann, Katharina Steinegger, Lara Trnovec, Daria Orekhova, Jonas Zähringer, Andreas Hörner, Valentin Fell, Philip Tinnefeld, Benjamin Winkeljann, Wolfgang Frieß, Olivia M Merkel*: Closing the Gap between Experiment and Simulation─ A Holistic Study on the Complexation of Small Interfering RNAs with Polyethylenimine.
Molecular Pharmaceutics 2024, doi:10.1021/acs.molpharmaceut.3c00747

Friederike Adams, Christoph M Zimmermann, Domizia Baldassi, Thomas M Pehl, Philipp Weingarten, Iris Kachel, Moritz Kränzlein, David C Jürgens, Peter Braubach, Ioannis Alexopoulos, Malgorzata Wygrecka, Olivia M Merkel*: Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis.
Small, 2023, e2308775. doi: 10.1002/smll.202308775.

Natascha Hartl, Bettina Gabold, Philipp Uhl, Adrian Kromer, Ximian Xiao, Walter Mier, Gert Fricker, Runhui Liu, Olivia M Merkel*:ApoE-functionalization of nanoparticles for targeted brain delivery-a feasible method for polyplexes?
Drug Delivery and Translational Research, 2023, doi: 10.1007/s13346-023-01482-w.

David C Jürgens, Benjamin Winkeljann, Miriam Kolog Gulko, Yoa Jin, Judith Möller, Joshua Winkeljann, Sahana Sheshachala, Alina Anger, Andreas Hörner, Nathan B P Adams, Nora Urbanetz, Olivia M Merkel*: Efficient and Targeted siRNA Delivery to M2 Macrophages by Smart Polymer Blends for M1 Macrophage Repolarization as a Promising Strategy for Future Cancer Treatment.
ACS Biomaterials Science and Engineering, 2024, 10 (1): 166-177.

Lea-Adriana Barlang, Kristina Weinbender, Olivia M Merkel, Andreas Popp: SARS-CoV-2 induced changes in the glycosylation pattern in the respiratory tract of Golden Syrian hamsters.
Drug Delivery and Translational Research, 2023, doi: 10.1007/s13346-023-01474-w.

Christoph M. Zimmermann, Leonie Deßloch, David C Jürgens, Paola Luciani, Olivia M. Merkel: Evaluation of the effects of storage conditions on spray-dried siRNA-LNPs before and after subsequent drying.
European Journal of Pharmaceutics and Biopharmaceutics, 2023, 193: 218-226

Karla Rubio, Jason M Müller, Aditi Mehta, Iris Watermann, Till Olchers, Ina Koch, Sabine Wessels, Marc A Schneider, Tania Araujo-Ramos, Indrabahadur Singh, Christian Kugler, Mircea Gabriel Stoleriu, Mark Kriegsmann, Martin Eichhorn, Thomas Muley, Olivia M Merkel, Thomas Braun, Ole Ammerpohl, Martin Reck, Achim Tresch, Guillermo Barreto: Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score.
Discover Oncology, 2023, 14 (1): 181.

Yao Jin, Friederike Adams, Anny Nguyen, Sebastian Sturm, Simone Carneiro, Olivia M Merkel*: Synthesis and application of spermine-based amphiphilic poly(β-amino ester)s for siRNA delivery.
Nanoscale Advances, 2023, 5 (19): 5256-5262.

Yao Jin, Friederike Adams, Lorenz Isert, Domizia Baldassi, Olivia M Merkel*: Spermine-Based Poly(β-amino ester)s for siRNA Delivery against Mutated KRAS in Lung Cancer.
Molecular Pharmaceutics, 2023, 20 (9): 4505-4516.

Lea-Adriana Barlang, Björn-Patrick Mohl, Claudia Blaurock, Sophia Harder, Angele Breithaupt, Olivia M Merkel, Anne Balkema-Buschmann, Andreas Popp: SARS-CoV-2 induced changes in the glycosylation pattern in the respiratory tract of Golden Syrian hamsters.
Acta Histochemica, 2023, 125 (7): 152077.

Natascha Hartl, David C Jürgens, Simone Carneiro, Ann-Christine König, Ximian Xiao, Runhui Liu, Stefanie M Hauck, Olivia M Merkel*: Protein corona investigations of polyplexes with varying hydrophobicity - From method development to in vitro studies.
International Journal of Pharmaceutics, 2023, 643: 123257.

Natascha Hartl, Bettina Gabold, Friederike Adams, Philipp Uhl, Sabrina Oerter, Sabine Gätzner, Marco Metzger, Ann-Christine König, Stefanie M Hauck, Antje Appelt-Menzel, Walter Mier, Gert Fricker, Olivia M Merkel*: Overcoming the blood-brain barrier? - prediction of blood-brain permeability of hydrophobically modified polyethylenimine polyplexes for siRNA delivery into the brain with in vitro and in vivo models.
Journal of Controlled Release, 2023, 360, 613-629.

David C Jürgens, Leonie Deßloch, Diana Porras-Gonzalez, Joshua Winkeljann, Sebastian Zielinski, Matthias Munschauer, Andreas L. Hörner, Gerald Burgstaller, Benjamin Winkeljann, Olivia M Merkel*: Lab-scale siRNA and mRNA LNP manufacturing by various microfluidic mixing techniques – an evaluation of particle properties and efficiency.
OpenNano, 2023, 12, 100161.

Antonietta Greco, Bettina Gabold, Siyu Chen, Xioaxuan Wang, Zehua Xu, Achim Hartschuh, Enrica Chiesa, Ida Genta, Christian L Ried, Thomas Merdan, Olivia M Merkel*: Microfluidic mixing as platform technology for production of chitosan nanoparticles loaded with different macromolecules.
European Journal of Pharmaceutics and Biopharmaceutics, 2023, 188, 170-181, 7757.

Lorenz Isert, Aditi Mehta, Gabriele Loiudice, Altea Oliva, Andreas Roidl, Olivia M Merkel*: An In-Vitro Approach to Model EMT in Breast Cancer.
International Journal of Molecular Science, 2023, 24 (9), 7757.

Rima Kandil, Domizia Baldassi, Sebastian Böhlen, Joschka T Müller, David C Jürgens, Tonia Bargmann, Susann Dehmel, Yuran Xie, Aditi Mehra, Olivia M Merkel*: GATA3 knockdown in activated T cells via pulmonary siRNA delivery as novel therapy for allergic asthma.
Journal of Controlled Release, 2023, 354, 305-315.

Yao Jin, Friederike Adams, Judith Möller, Lorenz Isert, Christoph Zimmermann, David Keul, Olivia M Merkel*: Synthesis and Application of Low Molecular Weight PEI-Based Copolymers for siRNA Delivery with Smart Polymer Blends.
Macromolecular Biosciences, 2023, 23 (2): e2200409.

Domizia Baldassi, Thi May Hanh Ngo, Olivia M Merkel*: Optimization of lung surfactant coating of siRNA polyplexes for pulmonary delivery.
Pharmaceutical Research, 2022, 29, 1-15.

Bettina Gabold, Friederike Adams, Sophie Brameyer, Kirsten Jung, Christian L. Ried, Thomas Merdan, Olivia M Merkel*:Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins.
Drug Delivery and Translational Research, 2023, 13(3), 822-838.

Christoph M. Zimmermann, Domizia Baldassi, Karen Chan, Nathan B.P. Adams, Alina Neumann, Diana Porras-Gonzalez, Xin Wei, Nikolaus Kneidinger, Mircea Gabriel Stoleriu, Andreas Popp, Gerald Burgstaller, Dominik Witzigmann, Paola Luciani, Olivia M. Merkel*: Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery
Journal of Controlled Release, 2022, 351, 137-150

Tobias W.M. Keil, Natalie Deiringer, Wolfgang Friess, Olivia M. Merkel*: Evaluation of adsorption of DNA/PEI polyplexes to tubing materials
European Journal of Pharmaceutics and Biopharmaceutics, 2022, 179, 58-64

Edmar R Oliveira-Filho, Matheus A de Macedo, Aline CC Lemos, Friederike Adams, Olivia M. Merkel, Marilda K Taciro, José Gregório C Gomzez, Luiziana F Silva: Engineering Burkholderia sacchari to enhance poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(3HB-co-3HHx)] production from xylose and hexanoate
International Journal of Biological Macromolecules, 2022, 213, 902-914

Domizia Baldassi, Shubhankar Ambike, Martin Feuerherd, Cho-Chin Cheng, David J Peeler, Daniel P Feldmann, Diana Porras-Gonzalez, Xin Wei, Lea Adriana Keller, Nikolaus Kneidinger, Mircea Gabriel Stoleriu, Andreas Popp, Gerald Burgstaller, Suzie H Pun, Thomas Michler, Olivia M. Merkel*: Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes
Journal of Controlled Release, 2022, 345, 661-674

Gemma Conte, Gabriella Costabile, Domizia Baldassi, Valeria Rondelli, Rosaria Bassi, Diego Colombo, Giulia Linardos, Ersilia V. Fiscarelli, Raffaella Sorrentino, Agnese Miro, Fabiana Quaglia, Paola Brocca, Ivana d’Angelo, Olivia M. Merkel, Francesca Ungaro: Hybrid lipid/polymer nanoparticles to tackle the cystic fibrosis mucus barrier in siRNA delivery to the lungs: does PEGylation make the difference?
ACS Applied Materials and Interfaces, 2022, 24, 6, 7565-7578

Shubhankar Ambike, Cho-Chin Cheng, Stoyan Velkov, Martin Feuerherd, Domizia Baldassi, Suliman Afridi, Diana Porras-Gonzalez, Xin Wei, Philipp Hagen, Nikolaus Kneidinger, Mircea Gabriel Stoleriu, Vincent Grass, Gerald Burgstaller, Andreas Pichlmair, Olivia Merkel, Chunkyu Ko, Thomas Michler: Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread.-
Nucleic Acids Research 2022, 50 (1), 333-349

Tobias W.M. Keil, Christoph Zimmermann, Domizia Baldassi, Friederike Adams, Wolfgang Friess, Aditi Mehta, Olivia M Merkel*: Impact of Crystalline and Amorphous Matrices on Successful Spray Drying of siRNA Polyplexes for Inhalation of Nano‐in‐Microparticles.
Advanced Therapeutics 2021, 4 (6), 2100073

Shubhankar Ambike, Cho-Chin Cheng, Suliman Afridi, Martin Feuerherd, Philipp Hagen, Vincent Grass, Olivia Merkel, Andreas Pichlmair, Chunkyu Ko, Thomas Michler: Systematic analysis of RNAi-accessible SARS-CoV-2 replication steps identifies ORF1 as promising target.
PREPRINT (Version 2) available at Research Square

Tobias W.M. Keil, Olivia M Merkel*: Characterization of positively charged polyplexes by tunable resistive pulse sensing.
European Journal of Pharmaceutics and Biopharmaceutics 2021,158, 359-364

Daniel P Feldmann, Joshua Heyza, Christoph M. Zimmermann, Steve M. Patrick, Olivia M Merkel*: Nanoparticle-Mediated Gene Silencing for Sensitization of Lung Cancer to Cisplatin Therapy.
Molecules 2020, 25 (8), 1994.

Patrick Strack Raimund Külzer, Florian Sommer, Tom Bretschneider, Olivia M Merkel, Achim Grube*: A Smart Approach to Enable Preclinical Studies in Pharmaceutical Industry: PLGA-based Extended Release Formulation Platform for Subcutaneous Applications
Drug Delivery and Industrial Pharmacy 2020, 46 (4), 635-645

Tobias W.M. Keil, Daniel P. Feldmann, Gabriella Costabilea, Qian Zhong, Sandro da Rocha, Olivia M Merkel*: Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles
European Journal of Pharmaceutics and Biopharmaceutics 2019, 143, 61-69

Aditi Mehta, Elena Dalle Vedove, Lorenz Isert, Olivia M Merkel*: Targeting KRAS mutant lung cancer cells with siRNA-loaded Bovine Serum Albumin nanoparticles
Pharmaceutical Research 2019, 36, (9), 133

Natascha Hartl, Friederike Adams, Gabriella Costabile, Lorenz Isert, Markus Döblinger, Ximian Xiano, Runhui Liu, Olivia M Merkel*: The Impact of Nylon-3 Copolymer Composition on the Efficiency of siRNA Delivery to Glioblastoma Cells.
Nanomaterials 2019, 9, (7), pii: E986. doi: 10.3390/nano9070986.

Rima Kandil, Yuran Xie, Ralf Heermann, Lorenz Isert, Kirsten Jung, Aditi Mehta, Olivia M Merkel*: Coming in and Finding Out: Blending Receptor‐Targeted Delivery and Efficient Endosomal Escape in a Novel Bio‐Responsive siRNA Delivery System for Gene Knockdown in Pulmonary T Cells.
Advanced Therapeutics 2019, https://doi.org/10.1002/adtp.201900047

Moses Andima, Gabriella Costabile, Lorenz Isert, Albert J Ndakala, Solomon Derese, Olivia M Merkel*: Evaluation of β-Sitosterol Loaded PLGA and PEG-PLA Nanoparticles for Effective Treatment of Breast Cancer: Preparation, Physicochemical Characterization, and Antitumor Activity.
Pharmaceutics 2018, 10 (4), pii E232

Gabriella Costabile, Kathrin I Gasteyer, Venkatareddy Nadithe, Katherine Van Denburgh, Qian Lin, Shiv Sharma, Joshia J Reineke, Steven M Firestine, Olivia M Merkel*: Physicochemical and In Vitro Evaluation of Drug Delivery of an Antibacterial Synthetic Benzophenone in Biodegradable PLGA Nanoparticles.
AAPS PharmSciTech 2018, 19 (8), 3561-70

Steven K Jones, Kirk Douglas, Anthony F Shields, Olivia M Merkel*: Correlating quantitative tumor accumulation and gene knockdown using SPECT/CT and bioluminescence imaging within an orthotopic ovarian cancer model.
Biomaterials 2018, 178, 183-192.

Elena Dalle Vedove, Gabriella Costabile, Olivia M Merkel*: Mannose and Mannose-6-Phosphate Receptor-Targeted Drug Delivery Systems and Their Application in Cancer Therapy.
Adv Healthc Mater 2018, e1701398. doi: 10.1002/adhm.201701398

Daniel P Feldmann, Yilong Cheng, Rima Kandil, Yuran Xie, Mariam Mohammadi, Hartmann Harz, Akhil Sharma, David J. Peeler, Anna Moszczynska, Heinrich Leonhardt, Suzie H. Pun, Olivia M Merkel*: In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells.
Journal of Controlled Release 2018, 276, 50-58

Jickssa M. Gemechu, Akhil Sharma, Dongyue Yu, Yuran Xie, Olivia M Merkel, Anna Moszczynska: Characterization of Dopaminergic System in the Striatum of Young Adult Park2−/−Knockout Rats.
Scientific Reports 2018, 8 (1), 1517

Steven K Jones, Anwesha Sarkar, Daniel P Feldmann, Peter Hoffmann, Olivia M Merkel*: Revisiting the value of competition assays in folate receptor-mediated drug delivery.
Biomaterials 2017, 138, 35-34.

Daniel P Feldmann, Yuran Xie, Steven K Jones, Dongyue Yu, Anna Moszczynska, Olivia M Merkel*: The impact of microfluidic mixing of triblock micelleplexes on in vitro/in vivo gene silencing and intracellular trafficking.
Nanotechnology 2017, 28 (22), 224001.

Yuran Xie, Bryan Killinger, Anna Moszczynska, Olivia M Merkel*: Targeted Delivery of siRNA to Transferrin Receptor Overexpressing Tumor Cells via Peptide Modified Polyethylenimine.
Molecules, 2016, 21 (10), E1334

Mariam Mohammadi, Ying Li, Daniel G Abebe, Yuran Xie, Rima Kandil, Teresa Kraus, Nardhy Gomez-Lopez, Tomoko Fujiwara, Olivia M Merkel*: Folate receptor targeted three-layered micelles and hydrogels for gene delivery to activated macrophages
Journal of Controlled Release, 2016, doi:10.1016/j.conrel.2016.08.020

Sara Movassaghian, Yuran Xie, Claudia Hildebrandt, Rayna Rosati, Ying Li, Na Hyung Kim, Denise S Conti, Sandro RP da Rocha, Zeng-Quan Yang, Olivia M Merkel*: Post-transcriptional regulation of the GASC1 oncogene with active tumor-targeted siRNA-nanoparticles
Molecular Pharmaceutics, 2016, 13 (8), 2605-21

Qian Zhong, Olivia M Merkel, Joshua J Reineke, Sandro RP da Rocha: Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution.
Molecular Pharmaceutics, 2016, 3 (6), 1886-78

Yuran Xie, Na Hyung Kim, Venkatareddy Nadithe, Dana Schalk, Archana Thakur, Ayşe Kılıç, Lawrence G Lum, David JP Bassett, Olivia M Merkel*: Targeted delivery of siRNA to activated T cells via transferrin-polyethyleneimine (Tf-PEI) as a potential therapy of asthma.
Journal of Controlled Release, 2016, 229, 120-9

Steven K Jones, Vincent Lizzio, Olivia M Merkel*: Folate Receptor Targeted Delivery of siRNA and Paclitaxel to Ovarian Cancer Cells via Folate Conjugated Triblock Copolymer to Overcome TLR4 Driven Chemotherapy Resistance.
Biomacromolecules, 2016, 17 (1), 76-87

Li Liu, Mengyao Zheng, Damiano Librizzi, Thomas Renette, Olivia M Merkel*, Thomas Kissel: Efficient and Tumor Targeted siRNA Delivery by Polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol)-folate (PEI-PCL-PEG-Fol).
Molecular Pharmaceutics, 2016, 13 (1), 134-43

Daniel Ghirmay Abebe, Rima Kandil, Teresa Kraus, Maha Elsayed, Olivia M Merkel*, Tomoko Fujiwara*: Three-Layered Biodegradable Micelles Prepared by Two-Step Self-Assembly of PLA-PEI-PLA and PLA-PEG-PLA Triblock Copolymers as Efficient Gene Delivery System
Macromolecular Bioscience, 2015, 15 (5), 698-717

Venkatareddy Nadithe, Runhui Liu, Na Hyung Kim, Bryan Killinger, Anna Moszczynska, Kristyn S Masters, Samuel H Gellman, Olivia M Merkel*: Screening of Nylon-3 Polymers, a New Class of Cationic Amphiphiles for siRNA Delivery
Molecular Pharmaceutics, 2015, 12 (2), 362-74

R. Michael Dutescu, Claudia Panfil, Olivia M Merkel, Norbert Schrage: Semifluorinated alkanes as liquid drug carrier systemfor topical ocular drug delivery
European Journal of Pharmaceutics and Biopharmaceutics 2014, 88(1), 123–128

Maha Elsayed, Vincent Corrand, Vidula Kolhatkar, Yuran Xie, Na Hyung Kim, Rohit Kolhatkar, Olivia M Merkel: The influence of oligospermine architecture on their suitability for siRNA delivery
Biomacromolecules 2014, 15 (4), 1299-1310

Thomas Endres, Mengyao Zheng, Ayşe Kılıç, Agnieszka Turowska, Moritz Beck-Broichsitter, Harald Renz, Olivia M. Merkel*, Thomas Kissel: Amphiphilic Biodegradable PEG-PCL-PEI Triblock Copolymers for FRET-Capable in Vitro and in Vivo Delivery of siRNA and Quantum Dots
Molecular Pharmaceutics 2014, 11(4), 1273–1281

Agnieszka Turowska, Damiano Librizzi, Nadja Baumgartl, Jens Kuhlmann, Tanja Dicke, Olivia Merkel, Ursula Homburg, Helmut Höffken, Harald Renz, Holger Garn: Biodistribution of the GATA-3-specific DNAzyme hgd40 after inhalative exposure in mice, rats and dogs
Toxicol Appl Pharmacol. 2013 Oct 15;272(2):365-72

Mengyao Zheng, Giovanni M. Pavan, Manuel Neeb, Andreas Schaper, Andrea Danani, Gerhard Klebe, Olivia M. Merkel*, Thomas Kissel: Targeting the blind spot of polycationic nanocarrier-based siRNA delivery
ACS Nano 2012, 6(11), 9447-54

Mengyao Zheng, Damiano Librizzi, Ayşe Kılıç, Yu Liu, Harald Renz, Olivia M. Merkel*, Thomas Kissel: Enhancing in vivo circulation and siRNA delivery with biodegradable polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol) copolymers
Biomaterials 2012, 33(27), 6551-8

Thomas Renette, Damiano Librizzi, Thomas Endres, Moritz Beck-Broichsitter, Nadja Bege, Olivia M. Merkel, Holger Petersen, Catherine Curdy, Thomas Kissel:Poly(ethylene carbonate) nanoparticles as carrier system for chemotherapy showing prolonged in vivo circulation and anti-tumor efficacy Macromolecular Bioscience 2012, 12(7), 970-8

Olivia M. Merkel and Thomas Kissel: Pulmonary siRNA Delivery
Accounts of Chemical Research 2012, 45(7), 961-70.

Nick D. Weber*, Olivia M. Merkel*, Thomas Kissel, María Angeles Muñoz-Fernández: PEGylated poly(ethylene imine) copolymer-delivered siRNA inhibits HIV replication in vitro
Journal of Controlled Release 2012, 157(1), 55-63

Mengyao Zheng, Yu Liu, Olga Samsonova, Olivia Merkel, Thomas Kissel: Amphiphilic and biodegradable hy-PEI-g-PCL-b-PEG copolymers efficiently mediate transgene expression depending on their graft density
International Journal of Pharmaceutics 2012, 427 (1),80-7

Yu Liu, Olga Samsonova, Brian Sproat, Olivia Merkel, Thomas Kissel: Biophysical characterization of hyper-branched polyethylenimine-graft- polycaprolactone-block-mono-methoxyl-poly(ethylene glycol) copolymers (hy- PEI-PCL-mPEG) for siRNA and DNA delivery
Journal of Controlled Release 2011, 153 (3), 262-268

Olga Samsonova, Christian Pfeiffer, Markus Hellmund, Olivia Merkel*, Thomas Kissel: Low molecular weight pDMAEMA-b-pHEMA block-copolymers synthesized via RAFTPolymerization: potential non-viral gene delivery agents?
Polymers 2011, 3, 693-718, *Corresponding Author

Olivia M. Merkel, Rudolf Urbanics, Peter Bedocs, Zoltán Rozsnyay, László Rosivall, Miklós Toth, Thomas Kissel, Janos Szebeni: In vitro and in vivo Complement Activation and Related Anaphylactic Effects Associated with Polyethylenimine and Polyethylenimine-graft-poly(ethylene glycol) Block Copolymers
Biomaterials 2011, 32, 4936-4942

Nadja Bege*, Thomas Renette*, Mirko Jansch, Regina Reul, Olivia Merkel, Holger Petersen, Catherine Curdy, Rainer H. Müller, Thomas Kissel: Poly(ethylene carbonate) nanoparticles: A novel biodegradable carrier system with “stealth” potential
Macromolecular Bioscience 2011, 11 (7), 897-904

Olivia M. Merkel*, Mengyao Zheng, Meredith A Mintzer, Giovanni M Pavan, Damiano Librizzi, Marek Maley, Helmut Höffken, Andrea Danani, Eric E Simanek, Thomas Kissel: Molecular modeling and in vivo imaging can identify
successful flexible triazine dendrimer-based siRNA delivery systems

Journal of Controlled Release 2011, 153 (1), 23-33, *Corresponding Author

Andrea Beyerle, Andrea Braun, Olivia Merkel, Felix Koch, Thomas Kissel, Tobias Stoeger: Comparative in vivo study of poly(ethylene imine)/sirna complexes for pulmonary delivery in mice
Journal of Controlled Release 2011, 151 (1), 51-56

Olivia M. Merkel, Andrea Beyerle, Benedikt Beckmann, Mengyao Zheng, Roland Hartmann, Tobias Stoeger, Thomas Kissel: Polymer-related off-target effects in non-viral siRNA delivery
Biomaterials 2011, 32 (9), 2388-2398

Olivia M. Merkel, Meredith A. Mintzer, Damiano Librizzi, Olga Samsonova, Tanja Dicke, Brian Sproat, Holger Garn, Peter J. Barth, Eric E.Simanek, Thomas Kissel:Triazine dendrimers as non-viral vectors for in vitro and in vivo RNAi: The effects of peripheral groups and core structure on biological activity
Molecular Pharmaceutics 2010, 7 (4), 969–983

Giovanni M. Pavan, Meredith Mintzer, Eric Simanek, Olivia M. Merkel, Thomas Kissel, Andrea Danani: Computational Insights into the Interactions between DNA and siRNA with “Rigid” and “Flexible” Triazine Dendrimers
Biomacromolecules 2010, 11 (3), 721-30

Andrea Beyerle, Olivia M. Merkel, Tobias Stöger and Thomas Kissel: PEGylation affects cytotoxicity and cell-compatibility of poly(ethylene imine) for lung application: Structure–function relationships
Toxicology and Applied Pharmacology 2010, 242 (2), 146-154

Olivia M. Merkel*, Meredith A. Mintzer*, Johannes Sitterberg, Udo Bakowsky, Eric E. Simanek and Thomas Kissel: Triazine dendrimers as nonviral gene delivery systems: effects of molecular structure on biological activity.
Bioconjugate Chemistry 2009, 20 (9), 1799-806

Olivia M. Merkel, Andrea Beyerle, Damiano Librizzi, Andreas Pfestroff, Thomas M. Behr, Brian Sproat, Peter J. Barth, Thomas Kissel: Nonviral siRNA Delivery to the Lung: Investigation of PEG-PEI Polyplexes and Their In Vivo Performance
Molecular Pharmaceutics 2009, 6 (4), 1246-60

Yu Liu, Juliane Nguyen, Terry Steele, Olivia Merkel, Thomas Kissel: A new synthesis method and degradation of hyper-branched polyethylenimine grafted polycaprolactone block mono-methoxyl poly (ethylene glycol) copolymers (hy-PEI-g-PCL-b-mPEG) as potential DNA delivery vectors
Polymer 2009, 50 (16), 3895-3904

Meredith A. Mintzer*, Olivia M. Merkel*, Thomas Kissel, Eric Simanek: Polycationic triazine-based dendrimers: Effect of peripheral groups on transfection efficiency
New J. Chem. 2009, 33, 1918 - 1925
*Both authors contributed equally to this work with synthesis (MAM) and biological and physicochemical characterization (OMM).

Olivia M. Merkel, Oliver Germershaus, Carol K. Wada, Peter J. Tarcha, Thomas Merdan and Thomas Kissel: Integrin alpha-v-beta-3 targeted gene delivery using RGD peptidomimetic conjugates with copolymers of PEGylated poly(ethylene imine)
Bioconjug Chem. 2009, 20 (6), 1270-1280

Olivia M. Merkel, Damiano Librizzi, Andreas Pfestroff, Tino Schurrat, Kevin Buyens, Niek N. Sanders, Stefaan DeSmedt, Martin Béhé and Thomas Kissel: Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging
J Control Release 2009, 138 (2), 148-159

Anastasia Malek, Olivia Merkel, Ludger Fink, Frank Czubayko, Thomas Kissel and Achim Aigner: In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes.
Toxicology and applied pharmacology 2009, 236 (1), 97-108

Olivia M. Merkel, Damiano Librizzi, Andreas Pfestroff, Tino Schurrat, Martin Béhé and Thomas Kissel: In vivo SPECT and real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery after novel radio labeling and purification
Bioconjugate Chemistry 2009, 20 (1), 174-182

Juliane Nguyen*, Terry W.J. Steele*, Olivia Merkel, Regina Reul and Thomas Kissel: Fast degrading polyesters as siRNA nano-carriers for pulmonary gene therapy
Journal of Controlled Release 2008, 132 (3), 243-251

Shirui Mao, Michael Neu, Oliver Germershaus, Olivia Merkel, Johannes Sitterberg, Udo Bakowsky, Thomas Kissel: Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly (ethylene imine)-graft-poly (ethylene glycol) block copolymer/ siRNA polyplexes
Bioconjugate Chem 2006, 17 (5), 1209 -1218

Peer Reviewed Reviews

Ouologuem L and Bartel K: Endolysosomal transient receptor potential mucolipins and two-pore channels: implications for cancer immunity.Front. Immunol. 15:1389194. 2024 doi: 10.3389/fimmu.2024.1389194.

Olivia M. Merkel*: Can pulmonary RNA delivery improve our pandemic preparedness?
Journal of Controlled Release, 2022, 345, 549-556

Hagar Labouta, Robert Langer, Pieter R Cullis, Olivia M Merkel, Mark R Prausnitz, Yasmine Gomaa, Dara S Nogueira, Tushar Kumeria: Role of drug delivery technologies in the success of COVID-19 vaccines: a perspective.
Drug Delivery and Translational Research 2022, doi: 10.1007/s13346-022-01146-1

Domizia Baldassi, Bettina Gabold, Olivia M. Merkel*: Air−Liquid Interface Cultures of the Healthy and Diseased Human Respiratory Tract: Promises, Challenges, and Future Directions.
Advanced NanoBiomed Research 2021, 1 (6), 202000111

Aditi Mehta, Thomas Michler, Olivia M. Merkel*: siRNA Therapeutics against Respiratory Viral Infections-What Have We Learned for Potential COVID-19 Therapies?
Advanced Healthcare Materials, 2021, 10 (7), e2001650

Lea-Adriana Keller, Olivia Merkel*, Andreas Popp: Intranasal drug delivery: opportunities and toxicologic challenges during drug development
Drug Delivery and Translational Research, 2021, doi:10.1007/s13346-020-00891-5

Natascha Hartl, Friederike Adams, Olivia M. Merkel*: From Adsorption to Covalent Bonding: Apolipoprotein E Functionalization of Polymeric Nanoparticles for Drug Delivery Across the Blood–Brain Barrier
Advanced Therapeutics, 2021, 4, 2000092.

Tobias W. M. Keil, Domizia Baldassi, Olivia M. Merkel*: T‐cell targeted pulmonary siRNA delivery for the treatment of asthma,
Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol., 2020, e1634.

Aditi Mehta, Olivia M. Merkel*: Immunogenicity of Cas9 Protein.
Journal of Pharmaceutical Sicences 2020, 109 (1), 62-67.

Rima Kandil, Olivia M. Merkel*: Recent Progress of Polymeric Nanogels for Gene Delivery.
Current Opinion in Colloid & Interface Science 2019, 39, 11-23

Haris Babačić, Aditi Mehta, Olivia M. Merkel, Benedikt Schoser: CRISPR-cas gene-editing as plausible treatment of neuromuscular and nucleotide-repeat-expansion diseases: A systematic review,
PLoS One 2019, 14 (2), e0212198

Juergen Siepmann, Amina Faham, Sophie-Dorothée Clas, Ben J. Boyd, Vincent Jannin, Andreas Bernkop-Schnürch, Hang Zhao, Sébastien Lecommandoux, James C. Evans, Christine Allen, Olivia M. Merkel, Gabriella Costabile, Morgan R. Alexander, Ricky D. Wildman, Clive J. Robert, Jean-Christophe Leroux: Lipids and polymers in pharmaceutical technology: Lifelong companions,
International Journal of Pharmaceutics 2019, 558, 128-142.

Steven Jones, Olivia M. Merkel*: Tackling Breast Cancer Chemoresistance with Nano-Formulated siRNA,
Nature Gene Therapy, 2016, 12, 821-828.

Rima Kandil, Olivia M. Merkel*: Therapeutic Delivery of siRNA: Diseases affecting the respiratory system,
Die Pharmazie, 2016, 71 (1), 21-26.

Yuran Xie, Olivia M. Merkel*: Pulmonary Delivery of siRNA via polymeric vectors as therapies of asthma,
Archiv der Pharmazie 2015, 348 (10), 681-688.

Sara Movassaghian, Olivia M. Merkel, Vladimir Torchilin*: Applications of Polymer Micelles for Imaging and Drug Delivery,
WIREs Nanomedicine and Nanobiotechnology 2014, 7 (5), 691-707.

Olivia M. Merkel*, Thomas Kissel: Quo vadis polyplex?, Journal of Controlled Release 2014, 190, 415-23

Olivia M. Merkel*, Israel Rubinstein, Thomas Kissel: siRNA Delivery to the lung: What's new?, Advanced Drug Delivery Reviews 2014, 75:112-28

Maha Elsayed, Olivia M. Merkel*: Nanoimprinting of topographical and 3D cell culture scaffolds, Nanomedicine (London) 2014, 9 (2), 349-366

Na Hyung Kim, Venkatareddy Nadithe, Maha Elsayed, Olivia M. Merkel*: Tracking and treating activated T cells, Journal of Drug Delivery Science and Technology 2013, 23 (1), 17-21

Moritz Beck-Broichsitter, Olivia M. Merkel, Thomas Kissel: Controlled pulmonary drug and gene delivery using polymeric nano-carriers, Journal of Controlled Release 2012, 161(2), 214-24

Olivia M. Merkel, Mengyao Zheng, Heiko Debus, Thomas Kissel: Pulmonary Gene Delivery Using Polymeric Nonviral Vectors, Bioconjugate Chemistry 2012, 23(1), 3-20

Book Chapters and Others

Aditi Mehta*, Olivia Merkel: Characterization Techniques for Studying the Properties of Nanocarriers for Systemic Delivery.
Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. 2020; 57-86.

Rima Kandil, Yuran Xie, Aditi Mehta, Olivia Merkel*: A Method for Targeted Nonviral siRNA Delivery in Cancer and Inflammatory Diseases.
Methods Mol Biol. 2020; 2059:155-166.

Daniel P Feldmann, Steven K Jones, Anthony F Shields, Olivia M Merkel*: Microfluidic Assembly of siRNA-Loaded Micelleplexes for Tumor Targeting in an Orthotopic Model of Ovarian Cancer.
Methods in Molecular Biology 2019, 1974, 355-369. *Corresponding Author

Gabriella Costabile, Olivia M. Merkel, Emerging Pulmonary Delivery Strategies in Gene Therapy: State of the Art and Future Considerations, Pharmaceutical Inhalation Aerosol Technology 2019, Chapter 15, CRC Press, pp.365-387. *Corresponding Author

Tobias WM Keil, Olivia M. Merkel, Dry powder inhalation of siRNA, Therapeutic Delivery 2019, 10 (5), 265-267.
Invited Editorial *Corresponding Author

Bettina Schwarz, Olivia M. Merkel, Nose-to-brain delivery of biologics, Therapeutic Delivery 2019, 10 (4), 207-210.
Invited Editorial *Corresponding Author

Rima Kandil, Olivia M. Merkel, Pulmonary delivery of siRNA as a novel treatment for lung diseases, Therapeutic Delivery 2019, 10 (4), 203-206.
Invited Editorial *Corresponding Author

Olivia M. Merkel*, Leigh Marsh, Holger Garn, Thomas Kissel: Flow cytometry-based cell type-specific assessment of target regulation by pulmonary siRNA delivery,
Methods in Molecular Biology 2019, 1943, 365-375, *Corresponding Author

Rima Kandil, Daniel Feldmann, Yuran Xie, Olivia M. Merkel*: Evaluating the Regulation of Cytokine Levels After siRNA Treatment in Antigen-Specific Target Cell Populations via Intracellular Staining,
Methods in Molecular Biology 2019, 1943, 323-331. *Corresponding Author

Bettina Schwarz, Olivia M. Merkel, Functionalized PEI and Its Role in Gene Therapy
Material Matters, 2017, 12.2

Rima Kandil, Jon Felt, Prashant Mahajan, Olivia M. Merkel: The Biology and Clinical Treatment of Asthma,
Nanomedicine for Inflammatory Diseases, 2017, CRC Press, pp.217-244. *Corresponding Author

Yuran Xie, Rima Kandil, Olivia M. Merkel: Bridging the Gap between the Bench and the Clinic: Asthma,
Nanomedicine for Inflammatory Diseases, 2017, CRC Press, pp.255-286. *Corresponding Author

Daniel G. Abebe, Rima Kandil, Teresa Kraus, Maha Elsayed, Tomoko Fujiwara, Olivia M. Merkel*: Biodegradable Three-Layered Micelles and Injectable Hydrogels, Methods in Molecular Biology 2016, 1445, 175-185. *Corresponding Author

Steven Jones, Olivia M. Merkel*: Indium-Labeling of siRNA for small animal SPECT Imaging , Methods in Molecular Biology 2016, 1372, 79-88.*Corresponding Author

Maha Elsayed, Olivia M. Merkel*: Inhaled Delivery of siRNA, "Advances and Challenges in the Delivery of Nucleic Acid Therapeutics", Vol 2, Future Science Press 2015. *Corresponding Author

Daniel P. Feldmann, Olivia M. Merkel*: The advantages of pulmonary delivery of therapeutic siRNA, Therapeutic Delivery 2015, 6 (4), 407-9, Invited Editorial *Corresponding Author

Mengyao Zheng, Thomas Kissel, Olivia M. Merkel*: Self-assembly of siRNA containing nanoparticles, Book Chapter in “RNA Nanotechnology and Therapeutics" , *Corresponding Author

Olivia M. Merkel*, Leigh Marsh, Holger Garn, Thomas Kissel: Flow cytometry-based cell type-specific assessment of target regulation by pulmonary siRNA delivery,
Methods in Molecular Biology 2013, 948, 263-73, *Corresponding Author

Meredith A. Mintzer, Olivia M. Merkel, Thomas Kissel, Eric E. Simanek: Triazine dendrimers for DNA and siRNA delivery: Progress, challenges, and opportunities
Wiley-VCH 2012, Dendrimer-Based Drug Delivery Systems, Chapter 10. Triazine dendrimers for DNA and siRNA delivery: Progress, challenges, and opportunities

Olivia M. Merkel*, Meredith A. Mintzer, Eric E. Simanek, Thomas Kissel: Perfectly shaped siRNA delivery
Therapeutic Delivery 2010, 1 (6), 737-742, Invited Editorial, *Corresponding Author

Olivia M. Merkel*, Meredith A. Mintzer, Eric Simanek, Thomas Kissel: Systematically modifying triazine dendrimers for efficient RNAi
Therapeutic Delivery 2010, 1 (2), 222, News and Views, Comment on Merkel et al, Mol Pharmaceutics 2010, *Corresponding Author

Olivia M. Merkel*, Thomas Kissel: [Pulmonary application of siRNA]
Lunge, Luft und Leben 2009, 7, 14-15, Research Report honoring the Promotion to Young Researchers awarded by the German Lung Foundation, *Corresponding Author

View my collection, "My Bibliography" from NCBI