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Domizia Baldassi

Domizia Baldassi (PhD Student)

Since Feb 2019 PhD student, LMU Munich
2018 MSc Intern, Merkel Lab, LMU Munich
2016 - 2018 MSc in Pharmaceutical Biotechnologies, University of Padova, Italy
2013 - 2016 BSc in Biotechnology, University of Trieste, Italy
Publications:

Friederike Adams, Christoph M Zimmermann, Domizia Baldassi, Thomas M Pehl, Philipp Weingarten, Iris Kachel, Moritz Kränzlein, David C Jürgens, Peter Braubach, Ioannis Alexopoulos, Malgorzata Wygrecka, Olivia M Merkel*: Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis.
Small, 2023, e2308775. doi: 10.1002/smll.202308775.

Yao Jin, Friederike Adams, Lorenz Isert, Domizia Baldassi, Olivia M Merkel*: Spermine-Based Poly(β-amino ester)s for siRNA Delivery against Mutated KRAS in Lung Cancer.
Molecular Pharmaceutics, 2023, 20 (9): 4505-4516.

Rima Kandil, Domizia Baldassi, Sebastian Böhlen, Joschka T Müller, David C Jürgens, Tonia Bargmann, Susann Dehmel, Yuran Xie, Aditi Mehra, Olivia M Merkel*: GATA3 knockdown in activated T cells via pulmonary siRNA delivery as novel therapy for allergic asthma.
Journal of Controlled Release, 2023, 354, 305-315.

Domizia Baldassi, Thi May Hanh Ngo, Olivia M Merkel*: Optimization of lung surfactant coating of siRNA polyplexes for pulmonary delivery.
Pharmaceutical Research, 2022, 29, 1-15.

Christoph M. Zimmermann, Domizia Baldassi, Karen Chan, Nathan B.P. Adams, Alina Neumann, Diana Porras-Gonzalez, Xin Wei, Nikolaus Kneidinger, Mircea Gabriel Stoleriu, Andreas Popp, Gerald Burgstaller, Dominik Witzigmann, Paola Luciani, Olivia M. Merkel*: Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery
Journal of Controlled Release, 2022, 351, 137-150

Domizia Baldassi, Shubhankar Ambike, Martin Feuerherd, Cho-Chin Cheng, David J Peeler, Daniel P Feldmann, Diana Porras-Gonzalez, Xin Wei, Lea Adriana Keller, Nikolaus Kneidinger, Mircea Gabriel Stoleriu, Andreas Popp, Gerald Burgstaller, Suzie H Pun, Thomas Michler, Olivia M. Merkel*: Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes
Journal of Controlled Release, 2022, 345, 661-674

Gemma Conte, Gabriella Costabile, Domizia Baldassi, Valeria Rondelli, Rosaria Bassi, Diego Colombo, Giulia Linardos, Ersilia V. Fiscarelli, Raffaella Sorrentino, Agnese Miro, Fabiana Quaglia, Paola Brocca, Ivana d’Angelo, Olivia M. Merkel, Francesca Ungaro: Hybrid lipid/polymer nanoparticles to tackle the cystic fibrosis mucus barrier in siRNA delivery to the lungs: does PEGylation make the difference?
ACS Applied Materials and Interfaces, 2022, 24, 6, 7565-7578

Shubhankar Ambike, Cho-Chin Cheng, Stoyan Velkov, Martin Feuerherd, Domizia Baldassi, Suliman Afridi, Diana Porras-Gonzalez, Xin Wei, Philipp Hagen, Nikolaus Kneidinger, Mircea Gabriel Stoleriu, Vincent Grass, Gerald Burgstaller, Andreas Pichlmair, Olivia Merkel, Chunkyu Ko, Thomas Michler: Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread.
Nucleic Acids Research 2021, doi.org/10.1093/nar/gkab1248

Domizia Baldassi, Bettina Gabold, Olivia M. Merkel*: Air−Liquid Interface Cultures of the Healthy and Diseased Human Respiratory Tract: Promises, Challenges, and Future Directions.
Advanced NanoBiomed Research 2021, doi:10.1002/anbr.202000111

Tobias W.M. Keil, Christoph Zimmermann, Domizia Baldassi, Friederike Adams, Wolfgang Friess, Aditi Mehta, Olivia M Merkel*: Impact of Crystalline and Amorphous Matrices on Successful Spray Drying of siRNA Polyplexes for Inhalation of Nano‐in‐Microparticles.
Advanced Therapeutics 2021, doi:10.1002/adtp.202100073

Tobias W. M. Keil, Domizia Baldassi, Olivia M. Merkel, T‐cell targeted pulmonary siRNA delivery for the treatment of asthma, Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol., 2020, e1634.