Dr. Simone Carneiro

Dr. Simone Pinto Carneiro (Postdoc)

Since July 2024 Group Leader, LMU Munich
July 2022- June 2024 Humboldt-Fellow, LMU Munich
2021-2022 Postdoc, LMU Munich
2019-2021: Postdoc, Universidade Federal de Ouro Preto (UFOP), Ouro Preto-MG, Brazil
2017-2018: Visiting PhD Student, Institut Galien Paris-Sud, Université Paris-Sud, Paris, France
2014-2018: PhD in Biotechnology, Universidade Federal de Ouro Preto (UFOP), Ouro Preto-MG, Brazil
2012-2012: Master Intern, Université Lille 2, Lille, France
2011-2013: M.Sc. in Pharmaceutical Sciences, Universidade Federal de Ouro Preto (UFOP), Ouro Preto-MG, Brazil
2005-2010: Degree in Pharmacy, Universidade Federal de Ouro Preto (UFOP), Ouro Preto-MG, Brazil

Publications:

S. Rademacker, S. Carneiro, M. Molbay, F. Catapano, I. Forné, A. Imhof, R. Wibel, C. Heidecke, P. Hölig, O. Merkel, The impact of lipid compositions on siRNA and mRNA lipid nanoparticle performance for pulmonary delivery, European Journal of Pharmaceutical Sciences, 2025, 107182, ISSN 0928-0987

F. Sieber-Schäfer, M. Jiang, A. Kromer, A. Nguyen, M. Molbay, S. Pinto Carneiro, D. Jürgens, G. Burgstaller, B. Popper, B. Winkeljann, O. M. Merkel, Machine Learning-Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery. Adv. Funct. Mater. 2025, e02805.

Siyu Chen, Anny Nguyen, Joschka T Müller, Müge Molbay, Aditi Mehta, Sahana Sheshachala, Kemal Baskaya, Nathan Adams, Simone P Carneiro, Olivia M Merkel*: Engineered-affibody conjugates contribute to the specific targeting and cellular retention of polyplexes in Erbb3 overexpressed lung cancer cells Eur J Pharm Sci 2025

Siyu Chen, Mariem Triki, Simone P Carneiro, Olivia M Merkel*: A Novel Micelleplex for Tumour-Targeted Delivery of CRISPR-Cas9 against KRAS-Mutated Lung Cancer
Nanoscale, 2025, DOI: 10.1039/D4NR03471F.

Marta Cabibbo, Cinzia Scialabba, Emanuela F Craparo E, Simone P Carneiro, Olivia M Merkel, Gennara Cavallaro: Diving into RNAi Therapy: An Inhalable Formulation Based on Lipid-Polymer Hybrid Systems for Pulmonary Delivery of siRNA
Biomacromolecules 2024: DOI: 10.1021/acs.biomac.4c00387

Siyu Chen, Simone P Carneiro, Olivia M Merkel: Anionic polymer coating for enhanced delivery of Cas9 mRNA and sgRNA nanoplexes
Biomaterials Science 2024: https://pubs.rsc.org/en/content/articlelanding/2025/bm/d4bm01290a

Carneiro, SP, Müller, JT, Merkel, OM: Fluorescent Techniques for RNA Detection in Nanoparticles. Methods in Molecular Biology, vol 2822. 2024. https://doi.org/10.1007/978-1-0716-3918-4_14

Carneiro S, Müller JT, Merkel OM. Targeted Molecular Therapeutics for Pulmonary Diseases: Addressing the Need for Precise Drug Delivery. Handb Exp Pharmacol. 2024 Jan 5. doi: 10.1007/164_2023_703.

Hartl N, Jürgens DC, Carneiro S, König AC, Xiao X, Liu R, Hauck SM, Merkel OM. Protein corona investigations of polyplexes with varying hydrophobicity - From method development to in vitro studies. Int J Pharm. 2023 Aug 25;643:123257. doi: 10.1016/j.ijpharm.2023.123257.

Carneiro SP, Greco A, Chiesa E, Genta I, Merkel OM. Shaping the future from the small scale: dry powder inhalation of CRISPR-Cas9 lipid nanoparticles for the treatment of lung diseases. Expert Opin Drug Deliv. 2023 Mar 12:1-17. doi: 10.1080/17425247.2023.21852

Patents:

SANTOS, O.D.H., PERASOLI, F.B., SILVA, L.S.B., FIGUEIREDO, B.I.C., BASTOS, J.C.S.A., CARNEIRO, S.P., TEIXEIRA, L. F. M. Single step process for preparation of nanocomposites constituted of poly(methyl methacrylate-co-dimethylacrylamide) with silver nanoparticles and general uses, Filling number: BR 10 2020 0129830

SANTOS, O.D.H., ANDRADE, M.H.G., CARVALHO, K.V., CARNEIRO, S.P. Method for development of rifampicin lipid nanoparticles entrapped in microparticles, Filling number: BR 10 2017 015666 4

SANTOS, O.D.H., CARNEIRO, S.P., JERONIMO, V.T., AGUIAR, T.A. Production of nanometric systems – clobetasol propionate nanoemulsions and polymeric nanocapsules associated to vegetal oils for topical use in dermatitis treatment, Filling number: BR 10 2013 010417 5