Adrian Kromer

Adrian Kromer (PhD Student)

adkroph@cup.

Since October 2022 PhD student, LMU Munich
2022 Master degree in Pharmaceutical Sciences in the field of Pharmaceutical Technology
2017 - 2022 Pharmacy School, LMU Munich

Müller, J.T., Caruso, S., Nguyen, A., Jürgens, D.,C., Kromer, A.P.E., Sheshachala, S., Adams, N.B.P., Merkel, O.M. Development of Trastuzumab-coupled, siRNA encapsulating mPolyplexes targeting HER2 overexpressing cancer cells. European Journal of Pharmaceutics and Biopharmaceutics, Volume 217, 2025, 114904, ISSN 0939-6411, https://doi.org/10.1016/j.ejpb.2025.114904.

Rademacker, S., Müller, J.T., Kromer, A.P.E., Carneiro, S.P., Merkel, O.M.  Nanoparticle-Mediated siRNA Delivery in Human Epithelial Lung Cells Cultured at the Air–Liquid Interface. In: Sioud, M. (eds) RNA Therapeutics. Methods in Molecular Biology, vol 2965. Humana, New York, NY. 2025 https://doi.org/10.1007/978-1-0716-4742-4_21

F. Sieber-Schäfer, M. Jiang, A. Kromer, A. Nguyen, M. Molbay, S. Pinto Carneiro, D. Jürgens, G. Burgstaller, B. Popper, B. Winkeljann, O. M. Merkel, Machine Learning-Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery. Adv. Funct. Mater. 2025, e02805.

Müller, JT, Kromer, APE, Ezaddoustdar, A, Alexopoulos, I, Steinegger, KM, Porras-Gonzalez, DL, Berninghausen, O, Beckmann, R, Braubach, P, Burgstaller, G, Wygrecka, M, and Merkel, OM*: Nebulization of RNA-Loaded Micelle-Embedded Polyplexes as a Potential Treatment of Idiopathic Pulmonary Fibrosis ACS Applied Materials & Interfaces DOI: 10.1021/acsami.4c21657

Steinegger, KM, Allmendinger, L, Sturm, S, Sieber-Schäfer, F, Kromer, APE, Müller-Caspary, K, Winkeljann, B, Merkel, OM*: Molecular Dynamics Simulations Elucidate the Molecular Organization of Poly(beta-amino ester) Based Polyplexes for siRNA Delivery
Nano Letters 2024: doi: 10.1021/acs.nanolett.4c04291

Kromer APE, Sieber-Schäfer F, Farfan Benito J, Merkel OM*: Design of Experiments Grants Mechanistic Insights into the Synthesis of Spermine-Containing PBAE Copolymers
ACS Applied Materials and Interfaces 2024, ahead of print, https://doi.org/10.1021/acsami.4c06079

Jin Y, Wang X, Kromer APE, Müller J, Zimmermann C, Xu Z, Hartschuh A, Adams F, Merkel OM: Role of Hydrophobic Modification in Spermine-Based Poly(β-amino ester)s for siRNA Delivery and Their Spray-Dried Powders for Inhalation and Improved Storage
Biomacromolecules 2024, ahead of print, doi: 10.1021/acs.biomac.4c00283

Hartl N, Gabold B, Uhl P, Kromer A, Xiao X, Mier W, Fricker G, Liu R, Merkel OM:ApoE-functionalization of nanoparticles for targeted brain delivery-a feasible method for polyplexes? Drug Delivery and Translational Research, 2023, doi: 10.1007/s13346-023-01482-w.