Dr. Gabriella Costabile

Dr. Gabriella Costabile

(Postdoc and STAR Fellow)

Since March 2019 Fondazione Veronesi Fellow at IIT Genova, Italy
November 2017 - March 2019 Group Leader, LMU Munich
March 2017 - October 2017 Postdoc and STAR Fellow, LMU Munich
2016-2017 Postdoc University of Naples, Italy
2016 PhD in Pharmaceutical Technology, University of Naples, Italy

Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles.
Keil TWM, Feldmann DP, Costabile G, Zhong Q, da Rocha S, Merkel OM.
Eur J Pharm Biopharm. 2019 Oct;143:61-69.

The Impact of Nylon-3 Copolymer Composition on the Efficiency of siRNA Delivery to Glioblastoma Cells.
Nanomaterials (Basel). 2019 Jul 8;9(7). pii: E986.

Lipids and polymers in pharmaceutical technology: lifelong companions
J. Siepmann, A. Faham, SD. Clas, B. Boyd, V. Jannin, A. Bernkop-Schnürch, H. Zhao, S. Lecommandoux, J.C. Evans, C. Allen, O.M. Merkel, G. Costabile, M.R. Alexander, R. Wildman, C. Roberts and JC. Leroux, Int J Pharm. 2019 Jan 9; 558:128-142. doi: 10.1016/j.ijpharm.2018.12.080.

Encapsulation of β-sitosterol in plga, peg-pla nanoparticles and its anticancer activity against mcf-7 and mda-mb23 breast cancer cells
M. Andima, G. Costabile, L. Isert, A.J. Ndakalab, S. Dereseb, O.M. Merkel, Pharmaceutics 2018, Nov 15 https://doi.org/10.3390/pharmaceutics10040232

Physicochemical and in vitro evaluation of drug delivery of an antibacterial synthetic benzophenone in biodegradable PLGA nanoparticles
G. Costabile, K.I. Gasteyer, V. Nadithe, K. Van Denburgh, Q. Lin, S. Sharma, J.J. Reineke, S.M. Firestine and O.M. Merkel, AAPS PharmSciTech. 2018 Sep 25. doi: 10.1208/s12249-018-1187-9

Mannose and Mannose-6-Phosphate Receptor-targeted Drug Delivery Systems and their application in Cancer Therapy
Dalle Vedove E, Costabile G, Merkel, OM, Advanced Healthcare Materials 2018, doi:10.1002/adhm.201701398

Development of inhalable hyaluronan/mannitol composite dry powders for flucytosine repositioning in local therapy of lung infections
Costabile G, d'Angelo I, d'Emmanuele di Villa Bianca R, Mitidieri E, Pompili B, Del Porto P, Leoni L, Visca P, Miro A, Quaglia F, Imperi F, Sorrentino R, Ungaro F., J Control Release. 2016 Sep 28;238:80-91. doi: 10.1016/j.jconrel.2016.07.029. Epub 2016 Jul 19.

Hybrid Lipid/Polymer Nanoparticles for Pulmonary Delivery of siRNA: Development and Fate Upon In Vitro Deposition on the Human Epithelial Airway Barrier.
d'Angelo I, Costabile G, Durantie E, Brocca P, Rondelli V, Russo A, Russo G, Miro A, Quaglia F, Petri-Fink A, Rothen-Rutishauser B, Ungaro F., J Aerosol Med Pulm Drug Deliv. 2017. doi: 10.1089/jamp.2017.1364.

Large Porous Particles for Sustained Release of a Decoy Oligonucelotide and Poly(ethylenimine): Potential for Combined Therapy of Chronic Pseudomonas aeruginosa Lung Infections., d'Angelo I, Perfetto B, Costabile G, Ambrosini V, Caputo P, Miro A, d'Emmanuele di Villa Bianca R, Sorrentino R, Donnarumma G, Quaglia F, Ungaro F., Biomacromolecules. 2016; 17 (5):1561-71

Skin transport of PEGylated poly(ε-caprolactone) nanoparticles assisted by (2-hydroxypropyl)-β-cyclodextrin., Conte C, Costabile G, d'Angelo I, Pannico M, Musto P, Grassia G, Ialenti A, Tirino P, Miro A, Ungaro F, Quaglia F., J Colloid Interface Sci. 2015; 454:112-20.

Toward Repositioning Niclosamide for Antivirulence Therapy of Pseudomonas aeruginosa Lung Infections: Development of Inhalable Formulations through Nanosuspension Technology., Costabile G, d'Angelo I, Rampioni G, Bondì R, Pompili B, Ascenzioni F, Mitidieri E, d'Emmanuele di Villa Bianca R, Sorrentino R, Miro A, Quaglia F, Imperi F, Leoni L, Ungaro F., Mol Pharm. 2015; 12 (8):2604-17