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David Jürgens

David Jürgens, né Keul (PhD Student)

Since January 2021 PhD student, LMU Munich
2020 Board License as a Pharmacist
2020 Pharmacy Resident, Ethris GmbH, Martiensried
2019 - 2020 Pharmacy Resident, Retail Pharmacy
2015 – 2019 Pharmacy School, LMU Munich


David C. Jürgens, Joschka T. Müller, Anny Nguyen, Olivia M Merkel*: Tailoring lipid nanoparticles for T-cell targeting in allergic asthma: Insights into efficacy and specificity.
European Journal of Pharmaceutics and Biopharmaceutics 2024, doi:10.1016/j.ejpb.2024.114242

Friederike Adams, Christoph M Zimmermann, Domizia Baldassi, Thomas M Pehl, Philipp Weingarten, Iris Kachel, Moritz Kränzlein, David C Jürgens, Peter Braubach, Ioannis Alexopoulos, Malgorzata Wygrecka, Olivia M Merkel*: Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis.
Small, 2023, e2308775. doi: 10.1002/smll.202308775.

David C Jürgens, Benjamin Winkeljann, Miriam Kolog Gulko, Yoa Jin, Judith Möller, Joshua Winkeljann, Sahana Sheshachala, Alina Anger, Andreas Hörner, Nathan B P Adams, Nora Urbanetz, Olivia M Merkel*: Efficient and Targeted siRNA Delivery to M2 Macrophages by Smart Polymer Blends for M1 Macrophage Repolarization as a Promising Strategy for Future Cancer Treatment.
ACS Biomaterials Science and Engineering, 2024, 10 (1): 166-177.

Christoph M. Zimmermann, Leonie Deßloch, David C Jürgens, Paola Luciani, Olivia M. Merkel: Evaluation of the effects of storage conditions on spray-dried siRNA-LNPs before and after subsequent drying.
European Journal of Pharmaceutics and Biopharmaceutics, 2023, 193: 218-226

Natascha Hartl, David C Jürgens, Simone Carneiro, Ann-Christine König, Ximian Xiao, Runhui Liu, Stefanie M Hauck, Olivia M Merkel*: Protein corona investigations of polyplexes with varying hydrophobicity - From method development to in vitro studies.
International Journal of Pharmaceutics, 2023, 643: 123257.

David C Jürgens, Leonie Deßloch, Diana Porras-Gonzalez, Joshua Winkeljann, Sebastian Zielinski, Matthias Munschauer, Andreas L. Hörner, Gerald Burgstaller, Benjamin Winkeljann, Olivia M Merkel*: Lab-scale siRNA and mRNA LNP manufacturing by various microfluidic mixing techniques – an evaluation of particle properties and efficiency.
OpenNano, 2023, 12, 100161.

Rima Kandil, Domizia Baldassi, Sebastian Böhlen, Joschka T Müller, David C Jürgens, Tonia Bargmann, Susann Dehmel, Yuran Xie, Aditi Mehra, Olivia M Merkel*: GATA3 knockdown in activated T cells via pulmonary siRNA delivery as novel therapy for allergic asthma.
Journal of Controlled Release, 2023, 354, 305-315.

Yao Jin, Friederike Adams, Judith Möller, Lorenz Isert, Christoph Zimmermann, David Keul, Olivia M Merkel*: Synthesis and Application of Low Molecular Weight PEI-Based Copolymers for siRNA Delivery with Smart Polymer Blends.
Macromolecular Biosciences, 2023, 23 (2): e2200409.

Engineering poly-and micelleplexes for nucleic acid delivery–A reflection on their endosomal escape
B Winkeljann, DC Keul, OM Merkel
Journal of Controlled Release 353, 518-534