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Dr. Benjamin Winkeljann

Dr. Benjamin Winkeljann (Postdoc)

2024-07 – present Principal Investigator

Comprehensive Pneumology Center Munich (CPC-M), Helmholtz Munich, German Center for Lung Research (DZL), Munich, Germany

2023-09 – present Co-Founder & Chief Executive Officer

RNhale GmbH, Munich, Germany

2023-07 – present University Lecturer Qualification (Habilitation)

Department for Pharmacy, Ludwig-Maximilians-University Munich, Germany

2023-04 – present Group Leader

Department for Pharmacy, Ludwig-Maximilians-University Munich, Germany

2021-04 – 2023-03 Postdoctoral Scientist

Department for Pharmacy, Ludwig-Maximilians-University Munich, Germany

2020-12 – 2021-03 Postdoctoral Scientist

Department of Mechanical Engineering and Munich School of Bioengineering, Technical University of Munich, Germany

2017-04 – 2020-11 PhD Candidate

Department for Mechanical Engineering, Technical University Munich, Germany

2015-04 – 2016-12 Master of Science Mechanical Engineering

Department for Mechanical Engineering, Technical University Munich, Germany

2011-10 – 2015-03 Bachelor of Science Mechanical Engineering

Department for Mechanical Engineering, Technical University Munich, Germany
Publications:

Selected publications (see https://orcid.org/0000-0002-6334-6696 for a complete list)

*equal contribution #correspondence

  1. K. M. Steinegger, L. Allmendinger, S. Sturm, F. Sieber-Schäfer, A. Kromer, K. Müller-Caspary, B. Winkeljann, and O. M. Merkel, Molecular dynamics simulations elucidate the molecular organization of poly(beta-amino ester) based polyplexes for siRNA delivery, Nano Letters 24 (49) 15683–15692 (2024).
  2. L. Hagedorn, D. C. Jürgens, O. M. Merkel, and B. Winkeljann#, Endosomal escape mechanisms of extracellular vesicle-based drug carriers: lessons for lipid nanoparticle design, Extracellular Vesicles and Circulating Nucleic Acids 5 (3), 344-357 (2024).
  3. J. Binder, J. Winkeljann, K. Steinegger, L. Trnovec, D. Orekhova, J. Zähringer, A. Hörner, V. Fell, P. Tinnefeld, B. Winkeljann#, W. Frieß and O. M. Merkel, Closing the gap between experiment and simulation – a holistic study on complexation of small interfering RNAs with polyethyleneimine, ACS Molecular Pharmaceutics 21 (5) 2163–2175 (2024).
  4. B. Winkeljann, D. C. Keul and O. M. Merkel, Engineering poly- and micelleplexes for nucleic acid delivery – A reflection on their endosomal escape, Journal of Controlled Release 353, 518-534 (2023).
  5. C. Kimna, B. Winkeljann, J. Hoffmeister and O. Lieleg, Biopolymer-based nanoparticles with tunable mucoadhesivity efficiently deliver therapeutics across the corneal barrier, Materials Science and Engineering: C 121, 111890 (2021)
Patents:
  1. O. M. Merkel, B. Winkeljann, D. C. Jürgens and L. Deßloch, Nano-in-micro encapsulated nucleic acid dry powder and pharmaceutical product containing said dry powder, International PCT application, PCT/EP2024/070691 (2023).
  2. O. Lieleg, B. Winkeljann, M. Marczynski and M. Weber-Hohengrund, Method of isolating mucin based on filtration steps, European patent, EP3967701 (2022).
  3. O. Lieleg, B. Winkeljann, M. Marczynski and M. Weber-Hohengrund, Method of isolating mucin from mucin containing tissue, European patent, EP3792275 (2021).
  4. O. Lieleg, C. Kimna and B. Winkeljann, Controlled release of compounds, International PCT application, PCT/EP2020/086972 (2021).